Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetMMP-2

Target IC₅₀: 17 nM, 30 nM against MMP-2, and MMP-9, respectively

General description

A potent inhibitor of MMP-2 (IC₅₀ = 17 nM) and MMP-9 (IC₅₀ = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.

A potent inhibitor of type IV collagenases, MMP-2 (IC₅₀ = 17 nM) and MMP-9 (IC₅₀ = 30 nM). Also shown to potently induce and rapidly activate HIF. Has been shown in vivo to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lauzier, M.C., et al. 2008. Mol. Pharmacol.In press.Mifune, M., et al. 2005. J. Biol. Chem.280, 26592. Zhang, H., et al. 2004. Circ. Res.95, 989. Tamura, Y., et al. 1998. J. Med. Chem.41, 640.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)